All Drugs Are Not Created Equal

All of us want cheaper medicine—but not if it costs us our health. Troubling reactions and a series of recalls are making some doctors wonder, Are generic drugs as safe as the FDA says they are? Self investigates.

Just when Beth Hubbard should have been feeling great, her health fell apart. A 34-year-old housewares designer in the St. Louis area, Hubbard had recently gotten married. She liked the creativity of her career. And she’d conquered her mild depression and fatigue with a combination of exercise, rest and medicine, including the antidepressant Wellbutrin XL. But in the fall of 2006, shortly after she refilled her prescription—her pharmacy giving her this time Budeprion XL, a generic version of the drug—her good health gave way.

Within a month, she had gained 15 pounds, couldn’t sleep well, developed gastrointestinal problems and felt such extreme fatigue and lack of motivation that she thought about quitting her job. She cried and called in sick for days at a time. "I chalked it up to exhaustion after the whirlwind of the wedding and honeymoon," Hubbard says.

Yet she wasn’t getting better. Her doctor referred her to four specialists, but none, she complains, "were really listening to me—they were just anxious to give me another drug." They diagnosed her alternately with severe allergies, a heart murmur, a slow thyroid, irritable bowel syndrome, gluten intolerance, mononucleosis and chronic pain. She cycled on and off different drugs: Ambien to help her sleep at night; Provigil to keep her awake during the day; Allegra, Zyrtec and Nasacort for allergies; Lexapro, Zoloft and Xanax for anxiety and depression; Zelnorm for bowel problems. And she continued on the Budeprion XL the entire time. "I was fighting for almost a year with the insurance company over all the tests and therapy I needed," Hubbard adds.

After eight months of struggling with her mystery ailments, she was out to dinner with a friend and mentioned that she needed to refill her prescription. Her friend said she’d recently gone off Wellbutrin and had some leftover pills Hubbard could use.

Within a week, Hubbard’s troubling symptoms vanished. Her energy came roaring back. And that is when she finally connected the dots: Her problems had begun mere days after she first took the generic. Because generics had always worked well for other conditions, she says, "I never even gave it a second thought or mentioned the pharmacy’s switch to my doctor." Until now.

She called her doctor to complain about the generic and request a new prescription for the brand name only. The nurse’s response floored her. "Yes" the nurse said matter-of-factly. "We hear that all the time."

Why Your M.D. is Worried READ THE FULL STORY HERE