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Boston Police Commissioner Ed Davis said Monday night that the death toll had risen to three. Scores were injured at the scene.
One of the dead was an 8-year-old boy, according to a state law enforcement source.
Hospitals reported at least 144 people are being treated, with at least 17 of them in critical condition and 25 in serious condition. At least eight of the patients are children.
At least 10 people injured had limbs amputated, according to a terrorism expert briefed on the investigation.
Doctors are "pulling ball bearings out of people in the emergency room," the expert said, suggesting the bombs were designed to propel shrapnel.
Several of the patients treated at Massachusetts General Hospital suffered injuries to lower limbs that will require "serial operations" in the coming days, trauma surgeon Peter Fagenholz said Monday night. Some injuries were so severe amputations were necessary, Fagenholz added.
In Washington, President Barack Obama vowed, "Any responsible individuals, any responsible groups, will feel the full weight of justice."
Boston "is a tough and resilient town," he said, adding that Americans will stand by Bostonians "every single step of the way."
'Like a huge cannon'
The terrorist attack, near the marathon's finish line, triggered widespread screaming and chaos, shattered windows and barricades and sent smoke billowing into the air at Copley Square.
The blasts were about 50 to 100 yards apart, officials said, on a stretch of the marathon course lined with spectators cheering runners through the final yards of a 26-mile, 385-yard endurance feat.
"It felt like a huge cannon," a witness told CNN about one of the blasts.
Allan Panter, a doctor who was near the finish line waiting for his wife to finish the race, told CNN he was standing about 20 to 25 feet from the first blast. He said he treated victims on the street after the explosion.
"I saw at least six to seven people down next to me," he said. "They protected me from the blast. One lady expired. One gentleman lost both his (lower) limbs. Most of the injuries were lower extremities."
Bill Iffrig, 78 and a veteran marathoner, was nearing the finish when "the shock waves just hit my whole body and my legs just started jittering around." Iffrig, who can be seen in video of the explosion wearing an orange tank top, was helped to his feet by an event volunteer and had just a scratch from his fall, he told CNN.
Federal authorities are classifying the bombings as a terrorist attack, but it's not clear whether the origin was domestic or foreign, a federal law enforcement official with knowledge of the investigation said.
A federal law enforcement official told CNN that both bombs were small, and initial tests showed no C-4 or other high-grade explosive material, suggesting that the packages used in the attack were crude explosive devices.
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