The accident happened on Coastal Highway at 67th Street in the northbound lanes.
The highway was closed in both directions. But as of 2:30 a.m., Jessica Waters, police spokeswoman, says northbound traffic is being diverted along the southbound lanes between 67th and 70th streets.
At least three people were injured, including a female who suffered serious burns to her legs, hands, forehead, nose and chin. Some were third-degree burns.
One report suggested that the vehicle had exploded. There was one radio report that also suggested that one of the vehicles involved in the accident could have been racing, but police will not confirm.
She says five people were transported to area hospitals; one person was sent to Bayview Medical Center for treatment of severe burns. The other four individuals had non-life threatening injuries.